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Gene Expression Data
Assay Details
Assay
Reference: J:110602 Lin L, et al., Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev Biol. 2006 Jul 15;295(2):756-63
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7258339
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175) (#9661)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 4C: embryonic day 10.0 (more )
Structure Level Pattern Image Note
TS16: outflow tract Ambiguous 4C
TS16: foregut epithelium Present Regionally restricted 4C Expression in ventral foregut endoderm.
Specimen 4D: embryonic day 10.0; Smotm1Amc/Smotm2Amc, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: outflow tract Present 4D Increased apoptosis in outflow tract myocardium relative to wildtype controls.
TS16: foregut epithelium Present Regionally restricted 4D No increase in expression in ventral foregut endoderm.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
MGI 6.24 		The Jackson Laboratory