Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Ostntm1Ncvc
Name:	osteocrin; targeted mutation 1, National Cerebral and Cardiovascular Center
MGI ID:	MGI:6877071
Synonyms:	OstnLacZ, OSTNtm1a(KOMP)ncvc
Gene:	Ostn  Location: Chr16:27126239-27169962 bp, + strand  Genetic Position: Chr16, 18.88 cM
Alliance:	Ostntm1Ncvc page

Germline Transmission:	Earliest citation of germline transmission: J:320628
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Targeting vector PG00061_Z_2_D09 from KOMP project was electroporated into ES cells. The targeting cassette is composed of En2 intron/splice-acceptor/exon, an IRES, the beta-galactosidase (LacZ) gene, a polyadenylation signal (pA) a loxP site, a beta-actin promoter, the neomycin-resistance gene (neo), a second pA site, second FRT site, and second loxP site. A third loxP site was inserted downstream of exon 3. In situ hybridization confirmed absence of mRNA in homozygotes. (J:320628)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ostn Mutation:	13 strains or lines available

Original:	J:320628 Watanabe-Takano H, et al., Mechanical load regulates bone growth via periosteal Osteocrin. Cell Rep. 2021 Jul 13;36(2):109380
All:	2 reference(s)