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Gene Expression Data
Assay Details
Assay
Reference: J:314133 Marczenke M, et al., GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium. Development. 2021 Nov 1;148(21):dev200080
Assay type: RNA in situ
MGI Accession ID: MGI:6866992
Gene symbol: Notch1
Gene name: notch 1
Probe: Mm-Notch1 (404641)
Probe preparation: Antisense
Visualized with: Fluorescein
Results
Specimen 3A Notch1 Control: embryonic day 8.5 (more )
Note: 8-9 somites
Structure Level Pattern Image Note
TS13: future prosencephalon Present Regionally restricted 3A Notch1 Control Expression in rostral neuroepithelium.

Specimen 3A Notch1 Gas1-/-: embryonic day 8.5; Gas1tm2Fan/Gas1tm2Fan (more )
Note: 8-9 somites
Structure Level Pattern Image Note
TS13: future prosencephalon Present Regionally restricted 3A Notch1 Gas1-/- Expression in rostral neuroepithelium comparable between genotypes.

Specimen 3B Notch1 Control: embryonic day 8.5 (more )
Note: 10-11 somites
Structure Level Pattern Image Note
TS13: future prosencephalon Present Regionally restricted 3B Notch1 Control Expression in rostral neuroepithelium.

Specimen 3B Notch1 Gas1-/-: embryonic day 8.5; Gas1tm2Fan/Gas1tm2Fan (more )
Note: 10-11 somites
Structure Level Pattern Image Note
TS13: future prosencephalon Weak Regionally restricted 3B Notch1 Gas1-/- Reduced expression in rostral neuroepithelium as early as E8.5 (10-11 somites).

Specimen 3C Notch1 Control: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future forebrain Present Regionally restricted 3C Notch1 Control Expression in rostral ventral neuroepithelium.

Specimen 3C Notch1 Gas1-/-: embryonic day 9.5; Gas1tm2Fan/Gas1tm2Fan (more )
Structure Level Pattern Image Note
TS15: future forebrain Weak Regionally restricted 3C Notch1 Gas1-/- Expression in rostral ventral neuroepithelium decreased compared with controls.

Specimen 3D Notch1 Control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forebrain Present Regionally restricted 3D Notch1 Control Expression in rostral ventral neuroepithelium.

Specimen 3D Notch1 Gas1-/-: embryonic day 10.5; Gas1tm2Fan/Gas1tm2Fan (more )
Structure Level Pattern Image Note
TS17: forebrain Weak Regionally restricted 3D Notch1 Gas1-/- Expression in rostral ventral neuroepithelium decreased compared with controls.

Specimen S4B Notch1 Control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: future spinal cord Present S4B Notch1 Control

Specimen S4B Notch1 Gas1-/-: embryonic day 10.5; Gas1tm2Fan/Gas1tm2Fan (more )
Structure Level Pattern Image Note
TS17: future spinal cord Present S4B Notch1 Gas1-/- Expression similar to that of controls.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory