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Gene Expression Data
Assay Details
Assay
Reference: J:65205 Marcinkiewicz M, et al., Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain. J Neurochem. 2000 Nov;75(5):2133-43
Assay type: RNA in situ
MGI Accession ID: MGI:6860352
Gene symbol: App
Gene name: amyloid beta precursor protein
Probe: betaAPP cDNA
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen E13: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: brain Present 1_APP e13
TS21: cranial ganglion Present 1_APP e13
TS21: glossopharyngeal ganglion Present 1_APP e13
TS21: spinal ganglion Present 1_APP e13
TS21: liver Absent 1_APP e13
Specimen E17: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: brain Present 1_APP e17
TS25: metanephros Present 1_APP e17
TS25: liver Absent 1_APP e17
Specimen P4 (medial): postnatal day 4 (more )
Structure Level Pattern Image Note
TS28: brain Present 1_APP p4(m)
TS28: cranial ganglion Present 1_APP p4(m)
TS28: metanephros Present 1_APP p4(m)
TS28: olfactory lobe Present 1_APP p4(m)
TS28: retina Present 1_APP p4(m)
TS28: skin Present 1_APP p4(m)
TS28: spinal ganglion Present 1_APP p4(m)
TS28: submandibular gland Present 1_APP p4(m)
TS28: bone marrow Absent 1_APP p4(m)
TS28: spleen Absent 1_APP p4(m)
TS28: thymus Absent 1_APP p4(m)
Specimen P4 (lateral): postnatal day 4 (more )
Structure Level Pattern Image Note
TS28: brain Present 1_APP p4(l)
TS28: cranial ganglion Present 1_APP p4(l)
TS28: metanephros Present 1_APP p4(l)
TS28: olfactory lobe Present 1_APP p4(l)
TS28: retina Present 1_APP p4(l)
TS28: skin Present 1_APP p4(l)
TS28: spinal ganglion Present 1_APP p4(l)
TS28: submandibular gland Present 1_APP p4(l)
TS28: bone marrow Absent 1_APP p4(l)
TS28: spleen Absent 1_APP p4(l)
TS28: thymus Absent 1_APP p4(l)
Specimen 2A: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cortical layer II Strong 2A
TS28: cortical layer VI Strong 2A
TS28: cortical layer III Strong 2A Expression was stronger in pyramidal cells.
TS28: cortical layer V Strong 2A Expression was stronger in pyramidal cells.
TS28: cortical layer IV Strong 2A Expression was weaker in granular cells.
Specimen 2D: postnatal adult (more )
Note: Relative hybridization densities were estimated by scanning autoradiographs.
Structure Level Pattern Image Note
TS28: choroid plexus Present 2D APP
TS28: cortical layer II Present 2D APP
TS28: cortical layer III Present 2D APP
TS28: cortical layer V Present 2D APP
TS28: cortical layer VI Present 2D APP
TS28: dentate gyrus Present 2D APP
TS28: dorsal thalamus Present 2D APP
TS28: hippocampus CA1 Present 2D APP
TS28: corpus callosum Present Regionally restricted 2D APP Expression is in oligodendrocytes.
Specimen not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: brain ependyma Absent
TS28: brain vascular element Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory