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Gene Expression Data
Assay Details
Assay
Reference: J:65205 Marcinkiewicz M, et al., Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain. J Neurochem. 2000 Nov;75(5):2133-43
Assay type: RNA in situ
MGI Accession ID: MGI:6860348
Gene symbol: Adam10
Gene name: a disintegrin and metallopeptidase domain 10
Probe: Adam10 CDNA2
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen E13: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: cranial ganglion Strong 1_ADAM10 e13
TS21: glossopharyngeal ganglion Strong 1_ADAM10 e13
TS21: brain Present Regionally restricted 1_ADAM10 e13 Expression is in cranial ganglia and is absent everywhere else in the brain.
TS21: liver Present 1_ADAM10 e13
Specimen E17: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: cerebral cortex Present Regionally restricted 1_ADAM10 e17 Expression is in the superficial cortical layers.
TS25: hippocampus Present 1_ADAM10 e17
TS25: liver Present 1_ADAM10 e17
Specimen P4 (medial): postnatal day 4 (more )
Structure Level Pattern Image Note
TS28: neocortex layer Present Regionally restricted 1_ADAM10 p4(m) Expression is in the superficial cortical layers.
TS28: bone marrow Present 1_ADAM10 p4(m)
TS28: hippocampus Present 1_ADAM10 p4(m)
TS28: olfactory lobe Present 1_ADAM10 p4(m)
TS28: retina Present 1_ADAM10 p4(m)
TS28: skin Present 1_ADAM10 p4(m)
TS28: spleen Present 1_ADAM10 p4(m)
TS28: submandibular gland Present 1_ADAM10 p4(m)
TS28: thymus Present 1_ADAM10 p4(m)
Specimen P4 (lateral): postnatal day 4 (more )
Structure Level Pattern Image Note
TS28: neocortex layer Present Regionally restricted 1_ADAM10 p4(l) Expression is in the superficial cortical layers.
TS28: bone marrow Present 1_ADAM10 p4(l)
TS28: hippocampus Present 1_ADAM10 p4(l)
TS28: olfactory lobe Present 1_ADAM10 p4(l)
TS28: retina Present 1_ADAM10 p4(l)
TS28: skin Present 1_ADAM10 p4(l)
TS28: spleen Present 1_ADAM10 p4(l)
TS28: submandibular gland Present 1_ADAM10 p4(l)
TS28: thymus Present 1_ADAM10 p4(l)
Specimen 2C: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cortical layer II Weak 2C
TS28: cortical layer VI Weak 2C
TS28: cortical layer III Weak 2C Expression was stronger in pyramidal cells.
TS28: cortical layer V Weak 2C Expression was stronger in pyramidal cells.
TS28: cortical layer IV Weak 2C Expression was weaker in granular cells.
Specimen 2D: postnatal adult (more )
Note: Relative hybridization densities were estimated by scanning autoradiographs.
Structure Level Pattern Image Note
TS28: choroid plexus Present 2D ADAM10
TS28: cortical layer II Present 2D ADAM10
TS28: cortical layer III Present 2D ADAM10
TS28: cortical layer V Present 2D ADAM10
TS28: cortical layer VI Present 2D ADAM10
TS28: dentate gyrus Present 2D ADAM10
TS28: dorsal thalamus Present 2D ADAM10
TS28: hippocampus CA1 Present 2D ADAM10
TS28: corpus callosum Present Regionally restricted 2D ADAM10 Expression is in oligodendrocytes.
Specimen 2G: postnatal adult (more )
Note: Double labeled: silver grains - Adam10; brown - App (assay MGI:6860367).
Structure Level Pattern Image Note
TS28: cerebral cortex Present 2G
Specimen not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: brain ependyma Absent
TS28: brain vascular element Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory