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Gene Expression Data
Assay Details
Assay
Reference: J:317044 Chen Y, et al., Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta. Nat Commun. 2021 Dec 10;12(1):7199
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6852574
Gene symbol: Col1a1
Gene name: collagen, type I, alpha 1
Antibody: anti-Type I Collagen (1310-01)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 3e WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: embryo Present 3e WT
Specimen 3e WT Tibia and Fibula: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: fibula Present 3e WT Tibia and Fibula
TS24: tibia Present 3e WT Tibia and Fibula
Specimen 3e WT Femur: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: femur Present 3e WT Femur
Specimen 3e WT Radius and Ulna: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: radius Present 3e WT Radius and Ulna
TS24: ulna Present 3e WT Radius and Ulna
Specimen 3e KO: embryonic day 16.5; Col1a1tm1a(EUCOMM)Wtsi/Col1a1tm1a(EUCOMM)Wtsi, Tg(S100a4-cre)1Egn/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: embryo Weak 3e KO Decreased collagen deposition in skeletal system.
Specimen 3e KO Tibia and Fibula: embryonic day 16.5; Col1a1tm1a(EUCOMM)Wtsi/Col1a1tm1a(EUCOMM)Wtsi, Tg(S100a4-cre)1Egn/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: fibula Weak 3e KO Tibia and Fibula Decreased collagen deposition in skeletal system.
TS24: tibia Weak 3e KO Tibia and Fibula Decreased collagen deposition in skeletal system.
Specimen 3e KO Femur: embryonic day 16.5; Col1a1tm1a(EUCOMM)Wtsi/Col1a1tm1a(EUCOMM)Wtsi, Tg(S100a4-cre)1Egn/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: femur Weak 3e KO Femur Decreased collagen deposition in skeletal system.
Specimen 3e KO Radius and Ulna: embryonic day 16.5; Col1a1tm1a(EUCOMM)Wtsi/Col1a1tm1a(EUCOMM)Wtsi, Tg(S100a4-cre)1Egn/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: radius Weak 3e KO Radius and Ulna Decreased collagen deposition in skeletal system.
TS24: ulna Weak 3e KO Radius and Ulna Decreased collagen deposition in skeletal system.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory