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Gene Expression Data
Assay Details
Assay
Reference: J:150616 Gutknecht L, et al., Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice. Eur Neuropsychopharmacol. 2009 Apr;19(4):266-82
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6840955
Gene symbol: Tph2
Gene name: tryptophan hydroxylase 2
Antibody: Tph2 antibody
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 4Ac: embryonic day 11.25 (more )
Structure Level Pattern Image Note
TS19: hindbrain Present Regionally restricted 4Ac Expression is near the floor plate in the rostro-ventral part of the hindbrain.
Specimen 4Ad: embryonic day 11.25 (more )
Structure Level Pattern Image Note
TS19: hindbrain Present Regionally restricted 4Ad Expression is near the floor plate in the rostro-ventral part of the hindbrain.
Specimen 4Bd: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: brainstem nucleus Present Regionally restricted 4Bd Expression is in serotonergic neurons in raphe nuclei.
Specimen 5Bf: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: brainstem nucleus Present Regionally restricted 5Bf Expression is in serotonergic neurons in raphe nuclei.
Specimen 5Bg: postnatal day 0.5 (more )
Structure Level Pattern Image Note
TS27: raphe nucleus Present 5Bg
Specimen 5Bh: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: raphe nucleus Present 5Bh
Specimen 5Bi: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: raphe nucleus Present 5Bi
Specimen 5Bj: postnatal day 16 (more )
Structure Level Pattern Image Note
TS28: raphe nucleus Present 5Bj Expression is serotonergic cells' soma from the most rostral central raphe nucleus to the most caudal obscurus raphe nucleus.
Specimen 6Bc: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: raphe nucleus Strong 6Bc
TS28: brain Present Regionally restricted 6Bc Expression is in fibers tracts such as the medial forebrain bundle, running along the floor of the aqueduct, above the corpus callosum, in the walls of the lateral ventricules, towards and within the bulbus olfactorius but also in isolated axons densely innervating all the different brain structures.
TS28: pineal gland Absent 6Bc
Specimen 6Bd: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: raphe nucleus Strong 6Bd Expression is in serotonergic axons presenting synaptic boutons and transversally cut axons.
Specimen 7Ba: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: pineal gland Absent 7Ba
Specimen 7Bb: postnatal day 0.5 (more )
Structure Level Pattern Image Note
TS27: pineal gland Present Regionally restricted 7Bb Expression is in fibers.
Specimen 7Bc: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: pineal gland Present Regionally restricted 7Bc Expression is in fibers.
Specimen 7Bd: postnatal adult (more )
Structure Level Pattern Image Note
TS28: pineal gland Weak Regionally restricted 7Bd Expression is in fibers.
Specimen 8a: postnatal (more )
Structure Level Pattern Image Note
TS28: dorsal raphe nucleus Present 8a
Specimen 8c: postnatal; Tph2tm1.2Kpl/Tph2tm1.2Kpl (more )
Structure Level Pattern Image Note
TS28: dorsal raphe nucleus Absent 8c
Specimen not shown: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: central nervous system Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory