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Gene Expression Data
Assay Details
Assay
Reference: J:307035 Chen NY, et al., Increased expression of LAP2beta eliminates nuclear membrane ruptures in nuclear lamin-deficient neurons and fibroblasts. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2107770118
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6832801
Gene symbol: Tmpo
Gene name: thymopoietin
Antibody: anti-LAP2
Results
Structure Level Pattern Image Note
TS26: cerebral cortex Present 1A LAP2beta Expression is evenly along the nuclear rim.
Specimen 1B Emx1-Cre;Lmnb1fl/fl;ROSAnT-nG: embryonic day 18.5; Emx1tm1(cre)Krj/Emx1+, Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees, Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: cerebral cortex Weak 1B LAP2beta In this mutant expression is reduced and/or unevenly distributed along the nuclear rim.
Structure Level Pattern Image Note
TS26: cortical plate Present 1C LAP2beta CP Expression is evenly along the nuclear rim.
Structure Level Pattern Image Note
TS26: cerebral cortex ventricular zone Present 1C LAP2beta VZ Expression is evenly along the nuclear rim.
Specimen 1D Emx1-Cre;Lmnb1fl/fl;ROSAnT-nG CP: embryonic day 18.5; Emx1tm1(cre)Krj/Emx1+, Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees, Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: cortical plate Weak 1D LAP2beta CP In this mutant expression is reduced and/or unevenly distributed along the nuclear rim.
Specimen 1D Emx1-Cre;Lmnb1fl/fl;ROSAnT-nG VZ: embryonic day 18.5; Emx1tm1(cre)Krj/Emx1+, Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees, Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: cerebral cortex ventricular zone Strong 1D LAP2beta VZ Expression is evenly along the nuclear rim.
Specimen S1A: postnatal month 3.5; Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy (more )
Structure Level Pattern Image Note
TS28: cerebral cortex Present S1A Lmbb+/+ top , S1A Lmnb1+/+ bottom Expression is evenly along the nuclear rim.
Specimen S1A Emx1-Cre Lmnb1fl/fl: postnatal month 3.5; Emx1tm1(cre)Krj/Emx1+, Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees, Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebral cortex Weak S1A Emx1-Cre;Lmnb1fl/fl bottom , S1A Emx1-Cre;Lmnb1fl/fl top In this mutant expression is reduced and unevenly distributed along the nuclear rim.
Specimen S1B: postnatal month 3.5; Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy (more )
Structure Level Pattern Image Note
TS28: cerebral cortex Present S1B Lmnb1+/+ bottom , S1B Lmnb1+/+ top Expression is evenly along the nuclear rim.
Specimen S1B Emx1-Cre Lmnb1fl/fl: postnatal month 3.5; Emx1tm1(cre)Krj/Emx1+, Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees, Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebral cortex Weak S1B Emx1-Cre;Lmnb1fl/fl top , S1B Emx1-Cre;Lmnb1fl/fl bottom In this mutant expression is reduced and unevenly distributed along the nuclear rim.
Specimen S3A Lmnb1fl/fl: embryonic day 18.5; Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy (more )
Note: Double labeled: red - Tmpo; green - Lmnb2 (assay MGI:6832807).
Structure Level Pattern Image Note
TS26: cerebral cortex Present S3A Lmnb1fl/fl LAP2beta , S3A Lmnb1fl/fl merge
Specimen S3A Emx1-Cre;Lmnb1fl/fl: embryonic day 18.5; Emx1tm1(cre)Krj/Emx1+, Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy (more )
Note: Conditional mutant. Double labeled: red - Tmpo; green - Lmnb2 (assay MGI:6832807).
Structure Level Pattern Image Note
TS26: cerebral cortex Present S3A Emx1-Cre;Lmnb1fl/fl LAP2beta , S3A Emx1-Cre;Lmnb1fl/fl merge In this mutant distribution was disproportionately to one side of the nucleus compared to controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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