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Gene Expression Data
Assay Details
Assay
Reference: J:226326 Greenlees R, et al., Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization. Hum Mol Genet. 2015 Oct 15;24(20):5789-804
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6828629
Gene symbol: Cdh1
Gene name: cadherin 1
Antibody: anti-E-cadherin
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 6G: embryonic day 18.5 (more )
Note: Double labeled: green - Cdh1; red - F-actin.
Structure Level Pattern Image Note
TS26: lens anterior epithelium Present 6G Basal and lateral staining, with an organized monolayer of anterior lens epithelial cells.
Specimen 6H: embryonic day 18.5; Sipa1l3Gt(EUCE0020a11)Hmgu/Sipa1l3Gt(EUCE0020a11)Hmgu (more )
Note: Double labeled: green - Cdh1; red - F-actin.
Structure Level Pattern Image Note
TS26: lens anterior epithelium Present 6H Basal and lateral staining, with disorganized arrangement of cell layers.
Specimen S4I: postnatal day 10 (more )
Note: Double labeled: green - Cdh1; red - F-actin.
Structure Level Pattern Image Note
TS28: lens anterior epithelium Present S4I Basal and lateral staining, with an organized monolayer of anterior lens epithelial cells.
Specimen S4J: postnatal day 10; Sipa1l3Gt(EUCE0020a11)Hmgu/Sipa1l3Gt(EUCE0020a11)Hmgu (more )
Note: Double labeled: green - Cdh1; red - F-actin.
Structure Level Pattern Image Note
TS28: lens anterior epithelium Present S4J Basal and lateral staining, with disorganized arrangement of cell layers.
Specimen S4K: postnatal day 10 (more )
Note: Double labeled: green - Cdh1; red - F-actin.
Structure Level Pattern Image Note
TS28: lens anterior epithelium Present S4K Basal and lateral staining, with an organized monolayer of anterior lens epithelial cells. Germinative/transition zone showed ordered F-actin staining in the anterior epithelium. Fibre cells elongated and formed linear and organized layers.
Specimen S4L: postnatal day 10; Sipa1l3Gt(EUCE0020a11)Hmgu/Sipa1l3Gt(EUCE0020a11)Hmgu (more )
Note: Double labeled: green - Cdh1; red - F-actin.
Structure Level Pattern Image Note
TS28: lens anterior epithelium Present S4L Basal and lateral staining, with disorganized arrangement of cell layers. Disorganized lens fibre cells (F-actin staining) were seen.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory