Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Pomc-dre)#Jcbr
Name:	transgene insertion, Jens C Bruning
MGI ID:	MGI:6828609
Synonyms:	POMCDre
Transgene:	Tg(Pomc-dre)#Jcbr  Location: unknown
Alliance:	Tg(Pomc-dre)#Jcbr page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Pomc-dre)#Jcbr expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Pomc (MGI:97742)   Mutation details: Using Red/ET recombination, the sequence encoding Dre recombinase together with a kanamycin/neomycin resistance cassette replaced the ATG start codon of the mouse Pomc gene of RP11-124K7 BAC clone. Five of seven transgenic lines showed similar specificity in the ARC and in the anterior and intermediate lobes of the pituitary. Line numbers were not indicated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:314806)

Activity:	Tissue activity of this recombinase allele
Driver:	Pomc (mouse) Summary of all recombinase alleles driven by Pomc. Comparative matrix view of recombinase activities Alliance mouse Pomc gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:314806 Biglari N, et al., Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci. 2021 Jul;24(7):913-929
All:	1 reference(s)