Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gcktm2885(icre)Thor
Name:	glucokinase; targeted mutation 2885, Bernard Thorens
MGI ID:	MGI:6810750
Synonyms:	Gckcre, Gcktm2885(icre)Arte, Gcktm2885(T2A-iCre)Arte
Gene:	Gck  Location: Chr11:5850820-5900081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Alliance:	Gcktm2885(icre)Thor page

Germline Transmission:	Earliest citation of germline transmission: J:313162
Parent Cell Line:	ART B6 3.6 (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Gcktm2885(icre)Thor expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gck (MGI:1270854)   Mutation details: Using homologous recombination in ES cells, a T2A-iCre sequence was inserted just before the Gck STOP signal in exon10, and an FRT-flanked positive selection marker puromycin was inserted in intron 8. (J:313162)

Activity:	Tissue activity of this recombinase allele
Driver:	Gck (mouse) Summary of all recombinase alleles driven by Gck. Comparative matrix view of recombinase activities Alliance mouse Gck gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gck Mutation:	59 strains or lines available

Original:	J:313162 Kessler S, et al., Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption. iScience. 2021 Oct 22;24(10):103122
All:	3 reference(s)