Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Nkx2-5tm1.1(cre/ERT2)Rard
Name:	NK2 homeobox 5; targeted mutation 1.1, Reza Ardehali
MGI ID:	MGI:6791388
Synonyms:	Nkx2-5/CreER
Gene:	Nkx2-5  Location: Chr17:27057638-27063962 bp, - strand  Genetic Position: Chr17, 13.6 cM
Alliance:	Nkx2-5tm1.1(cre/ERT2)Rard page

Germline Transmission:	Earliest citation of germline transmission: J:243421
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Nkx2-5tm1.1(cre/ERT2)Rard expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Nkx2-5 (MGI:97350)   Mutation details: Using homologous recombination in ES cells an internal ribosome entry site (IRES) linked to the gene encoding a nuclear-localizing recombinase cre fused to ERT2 and a hygromycin resistance gene cassette (pgk-HYGROpA) flanked by yeast flp recombinase target (frt) sites was inserted into the 3' UTR of the endogenous locus. pgk-HYGRO-pA cassette was removed by crossing to Flp recombinase gene expressing mice. (J:243421)

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx2-5 (mouse) Summary of all recombinase alleles driven by Nkx2-5. Comparative matrix view of recombinase activities Alliance mouse Nkx2-5 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:	21 strains or lines available

Original:	J:243421 Ranjbarvaziri S, et al., Generation of Nkx2-5/CreER transgenic mice for inducible Cre expression in developing hearts. Genesis. 2017 Aug;55(8)
All:	2 reference(s)