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Gene Expression Data
Assay Details
Assay
Reference: J:84425 Charalambous M, et al., Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8292-7
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6791377
Gene symbol: Grb10
Gene name: growth factor receptor bound protein 10
Reporter: lacZ
Direct Detection
Results
Specimen 4i: embryonic day 14.5; Grb10Gt(Betageo)1Ward/Grb10+ (more )
Note: bisected sagittally
Structure Level Pattern Image Note
TS22: lateral ventricle Present Regionally restricted 4i Expressed in the subependymal layer.
TS22: brain meninges Present 4i
TS22: choroid plexus epithelium Present 4i
TS22: choroid plexus stroma Present 4i
TS22: gut Present 4i
TS22: heart Present 4i
TS22: liver Present 4i
TS22: lung Present 4i
TS22: metanephros Present 4i
TS22: physiological umbilical hernia Present 4i
TS22: trunk musculature Present 4i
Specimen 4j left: embryonic day 12.5; Grb10Gt(Betageo)1Ward/Grb10+ (more )
Note: inherited the deletion maternally
Structure Level Pattern Image Note
TS20: brain meninges Present 4j left
TS20: face Present 4j left
TS20: limb cartilage condensation Present 4j left
TS20: rib pre-cartilage condensation Present 4j left
Specimen 4j right: embryonic day 12.5; Grb10Gt(Betageo)1Ward/Grb10+ (more )
Note: inherited the deletion paternally
Structure Level Pattern Image Note
TS20: brain meninges Present 4j right Expression was lower than that of a maternally transmitted.
TS20: face Present 4j right Expression was lower than that of a maternally transmitted.
TS20: limb cartilage condensation Present 4j right Expression was lower than that of a maternally transmitted.
TS20: rib pre-cartilage condensation Present 4j right Expression was lower than that of a maternally transmitted.
Specimen 4k left: embryonic day 14.5; Grb10Gt(Betageo)1Ward/Grb10+ (more )
Note: inherited the deletion paternally (internal view)
Structure Level Pattern Image Note
TS22: C2 vertebra Present 4k left
TS22: chondrocranium bone Present 4k left
TS22: gut Present 4k left
TS22: heart Present 4k left
TS22: limb cartilage condensation Present 4k left
TS22: lung Present 4k left
TS22: physiological umbilical hernia Present 4k left
TS22: rib cartilage condensation Present 4k left
TS22: tongue Present 4k left
TS22: skeletal muscle Absent 4k left
TS22: brain meninges Present Regionally restricted 4k left Expressed in the meninges of the fourth ventricle.
Specimen 4k right: embryonic day 14.5; Grb10Gt(Betageo)1Ward/Grb10+ (more )
Note: inherited the deletion paternally (external view)
Structure Level Pattern Image Note
TS22: brain meninges Present Regionally restricted 4k right Expressed in the meninges of the fourth ventricle.
TS22: limb cartilage condensation Present 4k right
TS22: physiological umbilical hernia Present 4k right
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory