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Derl1tm1.1Nishi
Targeted Allele Detail
Summary
Symbol: Derl1tm1.1Nishi
Name: Der1-like domain family, member 1; targeted mutation 1.1, Hideki Nishitoh
MGI ID: MGI:6781627
Synonyms: Derl1f
Gene: Derl1  Location: Chr15:57732898-57755814 bp, - strand  Genetic Position: Chr15, 24.06 cM, cytoband D2
Alliance: Derl1tm1.1Nishi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:311891
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation details: A pair of loxP sites were inserted to flank the exon 2 of the Derl1 gene by standard targeting method for homologous recombination in ES cells. The FRT flanked neomycin resistance cassette was also inserted in the intron 2 and later removed by Flp-mediated recombination. (J:311891)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Derl1 Mutation:  12 strains or lines available
References
Original:  J:311891 Sugiyama T, et al., ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. iScience. 2021 Jul 23;24(7):102758
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory