Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tbr1tm1.1(cre/ERT2)Maoc
Name:	T-box brain transcription factor 1; targeted mutation 1.1, Chai-An Mao
MGI ID:	MGI:6781269
Synonyms:	Tbr1TauGFPIRESCreERT2, Tbr1-TauGFP-IRESCreERT2
Gene:	Tbr1  Location: Chr2:61633274-61644458 bp, + strand  Genetic Position: Chr2, 35.56 cM
Alliance:	Tbr1tm1.1(cre/ERT2)Maoc page

Germline Transmission:	Earliest citation of germline transmission: J:281028
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Tbr1tm1.1(cre/ERT2)Maoc expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tbr1 (MGI:107404)   Mutation details: A Tbr1 (nonfunctional allele) were generated by inserting an Frt-PGKNeopA-Frt cassette and a synthetic TauGFP-IRESCreERT2 DNA fragment in the first exon behind the translation initiation codon ATG of Tbr1. The neo selection cassette was removed by FLP recombinase. (J:281028)

Activity:	Tissue activity of this recombinase allele
Driver:	Tbr1 (mouse) Summary of all recombinase alleles driven by Tbr1. Comparative matrix view of recombinase activities Alliance mouse Tbr1 gene page

In Mice Carrying this Mutation:

18 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbr1 Mutation:	38 strains or lines available

Original:	J:281028 Kiyama T, et al., Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse. Cell Rep. 2019 Apr 16;27(3):900-915.e5
All:	2 reference(s)