Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | Notes | References

Symbol:	Trpa1em1(icre)Kob
Name:	transient receptor potential cation channel, subfamily A, member 1; endonuclease-mediated mutation 1, Reiko Kobayakawa
MGI ID:	MGI:6781250
Synonyms:	Trpa1-Cre
Gene:	Trpa1  Location: Chr1:14942872-14989086 bp, - strand  Genetic Position: Chr1, 4.5 cM
Alliance:	Trpa1em1(icre)Kob page

Germline Transmission:	Earliest citation of germline transmission: J:305273
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Endonuclease-mediated (Recombinase) Mutation:    Insertion   Trpa1em1(icre)Kob expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Trpa1 (MGI:3522699)   Mutation details: Using CRISPR/Cas9-mediated genome editing in the ES cells, improved-Cre was inserted at the start codon of the endogenous mouse Trpa1 locus. (J:305273)

Activity:	Tissue activity of this recombinase allele
Driver:	Trpa1 (mouse) Summary of all recombinase alleles driven by Trpa1. Comparative matrix view of recombinase activities Alliance mouse Trpa1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpa1 Mutation:	92 strains or lines available

Original:	J:305273 Matsuo T, et al., Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation. Nat Commun. 2021 Apr 6;12(1):2074
All:	1 reference(s)