Tg(CD68-Il10)445Pmu
Transgene Detail
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| Symbol: |
Tg(CD68-Il10)445Pmu |
| Name: |
transgene insertion 445, Peter J Murray |
| MGI ID: |
MGI:6780161 |
| Synonyms: |
macIL-10tg |
| Transgene: |
Tg(CD68-Il10)445Pmu Location: unknown
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| Alliance: |
Tg(CD68-Il10)445Pmu page
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| Transgene Type: |
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Transgenic (Epitope tag, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(CD68-Il10)445Pmu expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Il10 (MGI:96537) |
"human promoter, mouse cDNA" |
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Mutation details: The transgene contains the following elements: the human CD68 promoter and intron 1, murine interleukin 3 signal peptide-coding sequence, in-frame with sequence coding for a FLAG tag, in-frame with the murine interleukin 10 cDNA without the signal peptide-coding sequence, and bovine growth hormone poly(A) signal sequence. An estimated 1-2 copies were inserted into the genome.
(J:75579)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:75579 Lang R, et al., Autocrine Deactivation of Macrophages in Transgenic Mice Constitutively Overexpressing IL-10 Under Control of the Human CD68 Promoter. J Immunol. 2002 Apr 1;168(7):3402-11 |
| All: |
1 reference(s) |
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Analysis Tools
