Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Oxttm1.1(icre)Ksak
Name:	oxytocin; targeted mutation 1.1, Kenji Sakimura
MGI ID:	MGI:6764587
Synonyms:	Oxtcre, Oxttm1.1(Cre)Ksak
Gene:	Oxt  Location: Chr2:130418093-130418974 bp, + strand  Genetic Position: Chr2, 63.24 cM
Alliance:	Oxttm1.1(icre)Ksak page

Germline Transmission:	Earliest citation of germline transmission: J:310161
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Oxttm1.1(icre)Ksak expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Oxt (MGI:97453)   Mutation details: The sequence of the self-processing furin-2A in front of the improved Cre (iCre) recombinase was inserted into the end of the coding sequence of the mouse Oxt gene. Frt flanked neo cassette was removed by crossing with the Actb-FLPe mouse line that expresses a Flp1 recombinase gene under the human ACTB promoter. (J:310161)

Activity:	Tissue activity of this recombinase allele
Driver:	Oxt (mouse) Summary of all recombinase alleles driven by Oxt. Comparative matrix view of recombinase activities Alliance mouse Oxt gene page

In Mice Carrying this Mutation:

7 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Oxt Mutation:	20 strains or lines available

Original:	J:310161 Fujima S, et al., CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior. J Neurosci. 2021 May 19;41(20):4524-4535
All:	1 reference(s)