Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Avpr1btm2.1(cre)Wsy
Name:	arginine vasopressin receptor 1B; targeted mutation 2.1, W Scott Young III
MGI ID:	MGI:6764454
Synonyms:	Avpr1b-Cre
Gene:	Avpr1b  Location: Chr1:131526977-131539738 bp, + strand  Genetic Position: Chr1, 57.09 cM, cytoband E4
Alliance:	Avpr1btm2.1(cre)Wsy page

Germline Transmission:	Earliest citation of germline transmission: J:310526
Parent Cell Line:	LC3 (ES Cell)
Strain of Origin:	(C57BL/6N x 129S6/SvEvTac)F1

Allele Type:    Targeted (Null/knockout, Recombinase) Mutations:    Insertion, Intragenic deletion   Avpr1btm2.1(cre)Wsy expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Avpr1b (MGI:1347010)   Mutation details: The Cre-nuclear localization sequence and FRT flanked pgk-neo cassette was inserted to replace the coding region from the initiating codon in exon 1 of the mouse Avpr1b gene by homologous recombination in the ES cells. The chimeras generated from correctly targetted ES cells were crossed to the FLPe deleter to remove the pgk-neo cassette. The absence of Avpr1b mRNA in brain of homozygous mice was confirmed. (J:310526)

Activity:	Tissue activity of this recombinase allele
Driver:	Avpr1b (mouse) Summary of all recombinase alleles driven by Avpr1b. Comparative matrix view of recombinase activities Alliance mouse Avpr1b gene page

In Mice Carrying this Mutation:

30 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Avpr1b Mutation:	33 strains or lines available

Original:	J:310526 Williams Avram SK, et al., NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression. Front Behav Neurosci. 2019;13:218
All:	2 reference(s)