About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:217191 Zhang Y, et al., Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis. Dev Biol. 2014 Dec 1;396(1):19-30
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6763230
Gene symbol: Mki67
Gene name: antigen identified by monoclonal antibody Ki 67
Antibody: anti-ki67
Detection system: Secondary antibody
Results
Specimen 8B Ki67 Control: embryonic day 12.5; Mdm4tm2Glo/Mdm4+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls. Triple labeled: green - Mki67; red - Pax6 (assay MGI:6763227); blue - DAPI.
Structure Level Pattern Image Note
TS20: lens vesicle anterior epithelium Present 8B Ki67 Control , 8B Control Merge
Specimen 8B Ki67 LE; MX f/f; p53 f/f: embryonic day 12.5; Mdm4tm2Glo/Mdm4tm2Glo, Tg(Pax6-cre,GFP)1Pgr/0, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Triple labeled: green - Mki67; red - Pax6 (assay MGI:6763227); blue - DAPI.
Structure Level Pattern Image Note
TS20: lens vesicle anterior epithelium Present 8B Ki67 LE; MX f/f; p53 f/f , 8B LE; MX f/f; p53 f/f Merge Authors report cell proliferation rate restored to 75% in MDMX (Mdm3) mutant mice.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory