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Gene Expression Data
Assay Details
Assay
Reference: J:217191 Zhang Y, et al., Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis. Dev Biol. 2014 Dec 1;396(1):19-30
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6763228
Gene symbol: Trp53
Gene name: transformation related protein 53
Antibody: anti-p53 (FL-393, sc-6243)
Detection system: Secondary antibody
Results
Specimen 3A p53 Control: embryonic day 10.0; Mdm2tm2.1Glo/Mdm2+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS16: lens pit Absent 3A p53 Control
Specimen 3A p53 LE; M2 f/f: embryonic day 10.0; Mdm2tm2.1Glo/Mdm2tm2.1Glo, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: lens placode Present 3A p53 LE; M2 f/f Expression easily detected in Mdm2-deleted lens epithelial cells.
Specimen 3B p53 E10 Control: embryonic day 10.0; Mdm4tm2Glo/Mdm4+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS16: lens pit Absent 3B p53 E10 Control
Specimen 3B p53 E10 LE; MX f/f: embryonic day 10.0; Mdm4tm2Glo/Mdm4tm2Glo, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: lens pit Weak 3B p53 E10 LE; MX f/f Expression in lens detected only with enhancement.
Specimen 3B p53 E10.5 Control: embryonic day 10.5; Mdm4tm2Glo/Mdm4+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS17: lens vesicle Absent 3B p53 E10.5 Control
Specimen 3B p53 LE; LE: MX f/f: embryonic day 10.5; Mdm4tm2Glo/Mdm4tm2Glo, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: lens pit Weak 3B p53 E10.5 LE; MX f/f Expression in lens detected only with enhancement.
Specimen 3B p53 E11 Control: embryonic day 11.0; Mdm4tm2Glo/Mdm4+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS18: lens vesicle Absent 3B p53 E11 Control
Specimen 3B p53 E11 LE; MX f/f: embryonic day 11.0; Mdm4tm2Glo/Mdm4tm2Glo, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS18: lens pit Weak 3B p53 E11 LE; MX f/f Expression in lens detected only with enhancement.
Specimen 7A p53 Control: embryonic day 10.0; Mdm2tm2.1Glo/Mdm2+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS16: lens pit Absent 7A p53 Control
Specimen 7A p53 LE; M2 f/f; p53 f/f: embryonic day 10.0; Mdm2tm2.1Glo/Mdm2tm2.1Glo, Tg(Pax6-cre,GFP)1Pgr/0, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: lens pit Absent 7A p53 LE; M2 f/f; p53 f/f Authors report loss of expression in mutant was confirmed.
Specimen 8A p53 Control: embryonic day 12.5; Mdm4tm2Glo/Mdm4+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS20: lens vesicle Ambiguous 8A p53 Control Expression in control was not discussed.
Specimen 8A p5 LE: MX f/f; p53 f/f: embryonic day 12.5; Mdm4tm2Glo/Mdm4tm2Glo, Tg(Pax6-cre,GFP)1Pgr/0, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: lens vesicle Absent 8A p53 LE; MX f/f; p53 f/f Authors report loss of expression in mutant was confirmed.
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03/18/2025
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