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Gene Expression Data
Assay Details
Assay
Reference: J:115783 Kiernan AE, et al., The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet. 2006 Jan;2(1):e4
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6763036
Gene symbol: Cdkn1b
Gene name: cyclin dependent kinase inhibitor 1B
Antibody: anti-p27Kip1
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 8A: embryonic day 14.5 (more )
Note: Basal turn. Double labeled: green - Cdkn1b; red - Jag1 (assay MGI:6763029).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 8A Positive prosensory domain did not overlap the Jag1+ domain.
Specimen 8B: embryonic day 14.5 (more )
Note: Basal turn. Double labeled: green - Cdkn1b; red - Sox2 (assay MGI:6763034).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 8B Positive prosensory domain did largely overlap the Sox2+ domain.
Specimen 8C: embryonic day 14.5; Jag1tm1Grid/Jag1tm2Grid, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant. Basal turn. Double labeled: green - Cdkn1b; red - Sox2 (assay MGI:6763034).
Structure Level Pattern Image Note
TS22: cochlea epithelium Weak Regionally restricted 8C Reduced expression compared with the controls. Expression was absent in the basal regions, only weak expression in the prosensory domain in the apex.
Specimen 8D: embryonic day 14.5 (more )
Note: Apical turn. Double labeled: green - Cdkn1b; red - Jag1 (assay MGI:6763029).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 8D Positive prosensory domain did not overlap the Jag1+ domain.
Specimen 8E: embryonic day 14.5 (more )
Note: Apical turn. Double labeled: green - Cdkn1b; red - Sox2 (assay MGI:6763034).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 8E Positive prosensory domain did largely overlap the Sox2+ domain.
Specimen 8F: embryonic day 14.5; Jag1tm1Grid/Jag1tm2Grid, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant. Apical turn. Double labeled: green - Cdkn1b; red - Sox2 (assay MGI:6763034).
Structure Level Pattern Image Note
TS22: cochlea epithelium Weak Regionally restricted 8F Reduced expression compared with the controls. Only weak expression in the prosensory domain in the apex.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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