Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tppp3tm2.1(cre/ERT2)Fan
Name:	tubulin polymerization-promoting protein family member 3; targeted mutation 2.1, Chen-Ming Fan
MGI ID:	MGI:6761419
Synonyms:	Tppp3ECE, Tppp3P2A-ERT2CreERT2
Gene:	Tppp3  Location: Chr8:106194125-106198158 bp, - strand  Genetic Position: Chr8, 53.04 cM, cytoband D1
Alliance:	Tppp3tm2.1(cre/ERT2)Fan page

Germline Transmission:	Earliest citation of germline transmission: J:282887
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv x C57BL/6J

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tppp3tm2.1(cre/ERT2)Fan expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tppp3 (MGI:1915221)   Mutation details: The CG(2A-ERT2-Cre-ERT2)-frt-neo-frt cassette was inserted upstream of the stop codon of the Tppp3 gene. No coding or 3UTR (untranslated region) sequences were deleted. Germline, flp mediated recombination removed the neo cassette. (J:282887)

Activity:	Tissue activity of this recombinase allele
Driver:	Tppp3 (mouse) Summary of all recombinase alleles driven by Tppp3. Comparative matrix view of recombinase activities Alliance mouse Tppp3 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tppp3 Mutation:	19 strains or lines available

Original:	J:282887 Harvey T, et al., A Tppp3(+)Pdgfra(+) tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis. Nat Cell Biol. 2019 Dec;21(12):1490-1503
All:	1 reference(s)