Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Pax9tm1.1(cre)Sbam
Name:	paired box 9; targeted mutation 1.1, Simon Bamforth
MGI ID:	MGI:6760663
Synonyms:	Pax9Cre
Gene:	Pax9  Location: Chr12:56738552-56759607 bp, + strand  Genetic Position: Chr12, 24.53 cM
Alliance:	Pax9tm1.1(cre)Sbam page

Germline Transmission:	Earliest citation of germline transmission: J:284143
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout, Recombinase) Mutations:    Insertion, Intragenic deletion   Pax9tm1.1(cre)Sbam expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Pax9 (MGI:97493)   Mutation details: The targeting construct was designed to replace a 1.06 kb section of the mouse Pax9 gene, spanning the second half of exon two, containing the start codon, and the first half of the 3rd exon, containing the paired box and octapeptide motif, with a promoterless Cre recombinase gene preceded by a consensus Kozak sequence and the FRT-flanked PGK-Neomycin cassette. After homologous recombination in ES cells, the FRT-flanked PGK-neomycin cassette was removed by crossing the derived mice with FLPe mice. (J:284143)

Activity:	Tissue activity of this recombinase allele
Driver:	Pax9 (mouse) Summary of all recombinase alleles driven by Pax9. Comparative matrix view of recombinase activities Alliance mouse Pax9 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pax9 Mutation:	16 strains or lines available

Original:	J:284143 Phillips HM, et al., Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis. Development. 2019 Sep 23;146(18):dev177618
All:	3 reference(s)