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Gene Expression Data
Assay Details
Assay
Reference: J:149478 Mao J, et al., Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell. 2009 Apr;16(4):600-6
Assay type: RNA in situ
MGI Accession ID: MGI:6758944
Gene symbol: Hand2
Gene name: heart and neural crest derivatives expressed 2
Probe: Hand2 probe11
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 3B R26-EtvEnR: embryonic day 10.5; Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS17: limb mesenchyme Present Regionally restricted 3B R26-EtvEnR Hand2
Specimen 3B Prx1-Cre;R26-EtvEnR: embryonic day 10.5; Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: limb mesenchyme Present Regionally restricted 3B Prx1-Cre;R26-EtvEnR Hand2 There is an upregulation and anterior expansion in the expression domain in this mutant compared to controls.
Specimen S3B R26-EtvEnR: embryonic day 9.25; Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS15: limb mesenchyme Present Regionally restricted S3B R26-EtvEnR Hand2
Specimen S3B Prx1-Cre;R26-EtvEnR: embryonic day 9.25; Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: limb mesenchyme Present Regionally restricted S3B Prx1-Cre;R26-EtvEnR Hand2 Expression in this mutant is the same as in controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory