Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tbx21tm2.1(cre)Ayr
Name:	T-box 21; targeted mutation 2.1, Alexander Y Rudensky
MGI ID:	MGI:6758783
Synonyms:	Tbx21tdTomato-T2A-cre
Gene:	Tbx21  Location: Chr11:96988897-97006157 bp, - strand  Genetic Position: Chr11, 60.95 cM, cytoband D
Alliance:	Tbx21tm2.1(cre)Ayr page

Germline Transmission:	Earliest citation of germline transmission: J:248943
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Recombinase, Reporter) Mutation:    Insertion   Tbx21tm2.1(cre)Ayr expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tbx21 (MGI:1888984)   Mutation details: The IRES-tdTomato-T2A-Cre-frt-NEO-BGHpA-frt sequence was inserted into the Tbx21 3' UTR by homologous recombination in the ES cells. Mice were bred to FLPeR mice to excise the NEO cassette. (J:248943)

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx21 (mouse) Summary of all recombinase alleles driven by Tbx21. Comparative matrix view of recombinase activities Alliance mouse Tbx21 gene page

In Mice Carrying this Mutation:

16 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx21 Mutation:	36 strains or lines available

Original:	J:248943 Levine AG, et al., Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 2017 Jun 15;546(7658):421-425
All:	4 reference(s)