Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Aurkbtm1.1(cre/ERT2)Deli
Name:	aurora kinase B; targeted mutation 1.1, Deqiang Li
MGI ID:	MGI:6758108
Synonyms:	AurkbER Cre
Gene:	Aurkb  Location: Chr11:68936473-68942490 bp, + strand  Genetic Position: Chr11, 42.32 cM
Alliance:	Aurkbtm1.1(cre/ERT2)Deli page

Germline Transmission:	Earliest citation of germline transmission: J:309046
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter) Mutation:    Insertion   Aurkbtm1.1(cre/ERT2)Deli expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Aurkb (MGI:107168)   Mutation details: The allele was generated by homologous recombination in embryonic stem cells targeting a Cre-Ert2-V2A-tdTomato-Frt-PGK-neo-Frt cassette into the start codon of the Aurkb locus. The PGK-Neo cassette was removed by breeding the initial progeny to mice expressing Flpe recombinase. (J:309046)

Activity:	Tissue activity of this recombinase allele
Driver:	Aurkb (mouse) Summary of all recombinase alleles driven by Aurkb. Comparative matrix view of recombinase activities Alliance mouse Aurkb gene page

In Mice Carrying this Mutation:

8 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aurkb Mutation:	23 strains or lines available

Original:	J:309046 Jang J, et al., An Engineered Mouse to Identify Proliferating Cells and Their Derivatives. Front Cell Dev Biol. 2020;8:388
All:	1 reference(s)