Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Oprm1tm2.1(EGFP/cre)Ics
Name:	opioid receptor, mu 1; targeted mutation 2.1, Mouse Clinical Institute
MGI ID:	MGI:6755589
Synonyms:	Oprm1-Cre, Oprm1tm5.1(EGFP/cre)Kff
Gene:	Oprm1  Location: Chr10:6708593-6988209 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Alliance:	Oprm1tm2.1(EGFP/cre)Ics page

Germline Transmission:	Earliest citation of germline transmission: J:288326
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (No functional change, Recombinase, Reporter) Mutation:    Insertion   Oprm1tm2.1(EGFP/cre)Ics expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Oprm1 (MGI:97441)   Mutation details: A targeting vector was designed to insert a T2A-EGFP/Cre fusion protein in exon 4 in frame just upstream of the stop codon, of the opioid receptor, mu 1 (Oprm1) coding region. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:288326)

Activity:	Tissue activity of this recombinase allele
Driver:	Oprm1 (mouse) Summary of all recombinase alleles driven by Oprm1. Comparative matrix view of recombinase activities Alliance mouse Oprm1 gene page

In Mice Carrying this Mutation:

13 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:	53 strains or lines available

Original:	J:288326 Bailly J, et al., Targeting Morphine-Responsive Neurons: Generation of a Knock-In Mouse Line Expressing Cre Recombinase from the Mu-Opioid Receptor Gene Locus. eNeuro. 2020 May/Jun;7(3):ENEURO.0433-19.2020
All:	1 reference(s)