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Gene Expression Data
Assay Details
Assay
Reference: J:308800 Ah-Cann C, et al., A functional genetic screen identifies aurora kinase b as an essential regulator of Sox9-positive mouse embryonic lung progenitor cells. Development. 2021 Jul 1;148(13):dev199543
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6755212
Gene symbol: Nkx2-1
Gene name: NK2 homeobox 1
Antibody: Anti-Thyroid Transcription Factor (TTF-1) Clone 8G7G3/1
Assay notes: Authors state that Aurkbfl/fl and Aurkbfl/+;Shh-cre mice were phenotypically identical, and used either as Aurkb Ct controls.
Results
Specimen 4D Aurkb Ct Nkx2.1: embryonic day 11.5; Aurkbtm1.1Mama/Aurkbtm1.1Mama (more )
Structure Level Pattern Image Note
TS19: trachea Present 4D Aurkb Ct Nkx2.1
Specimen 4D Aurkb Shh-Cre Nkx2.1: embryonic day 11.5; Aurkbtm1.1Mama/Aurkbtm1.1Mama, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: trachea Present 4D Aurkb Shh-Cre Nkx2.1 Expression in remnant ot trachea, indicating separation of trachea from esophagus and lung specification had occurred.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory