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Gene Expression Data
Assay Details
Assay
Reference: J:308800 Ah-Cann C, et al., A functional genetic screen identifies aurora kinase b as an essential regulator of Sox9-positive mouse embryonic lung progenitor cells. Development. 2021 Jul 1;148(13):dev199543
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6755210
Gene symbol: Sox9
Gene name: SRY (sex determining region Y)-box 9
Antibody: anti-Sox9 (AF3075)
Assay notes: Assay used light sheet imaging. Authors state that Aurkbfl/fl and Aurkbfl/+;Shh-cre mice were phenotypically identical, and used either as Aurkb Ct controls.
Results
Specimen 4E Aurkb Ct Sox9: embryonic day 11.5; Aurkbtm1.1Mama/Aurkbtm1.1Mama (more )
Note: Triple labeled: yellow - Sox9; pink - E-cadherin (Cdh1 assay MGI:6755208); blue - DAPI.
Structure Level Pattern Image Note
TS19: lung Present Regionally restricted 4E Aurkb Ct merge , 4E Aurkb Ct Sox9 Expression clearly observed at tips of branching lung buds.
TS19: trachea Present 4E Aurkb Ct Sox9 Expression in precursors of cartilage of trachea.
Specimen 4E Aurkb Shh-Cre Sox9: embryonic day 11.5; Aurkbtm1.1Mama/Aurkbtm1.1Mama, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Triple labeled: yellow - Sox9; pink - E-cadherin (Cdh1 assay MGI:6755208); blue - DAPI.
Structure Level Pattern Image Note
TS19: lung Absent 4E Aurkb Shh-Cre Sox9 , 4E Aurkb Shh-Cre merge
TS19: trachea Present 4E Aurkb Shh-Cre Sox9 , 4E Aurkb Shh-Cre merge Expression in precursors of cartilage of trachea.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
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