Tg(Ttr-Proc*)#Wlr
Transgene Detail
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| Symbol: |
Tg(Ttr-Proc*)#Wlr |
| Name: |
transgene insertion, Harmut Weiler |
| MGI ID: |
MGI:6755161 |
| Synonyms: |
APCHI, mAPCHI |
| Transgene: |
Tg(Ttr-Proc*)#Wlr Location: unknown
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| Alliance: |
Tg(Ttr-Proc*)#Wlr page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Tg(Ttr-Proc*)#Wlr expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Proc (MGI:97771) |
mouse cDNA with D168F and N173K codon changes (coordinates for mature peptide) |
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Mutation details: A cDNA for a mutagenized murine protein C gene where D168F and N173K codon changes (D209F, N214K for pre-pro-peptide) were introduced, was placed in exon 2 in a 3 kb fragment containing the promoter and exons 1 and 2 of the liver-specific transthyretin gene. The mutations create a hyper-activatable form of the enzyme.
(J:306712)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:306712 van Mens TE, et al., Variable phenotypic penetrance of thrombosis in adult mice after tissue-selective and temporally controlled Thbd gene inactivation. Blood Adv. 2017 Jun 27;1(15):1148-1158 |
| All: |
2 reference(s) |
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Analysis Tools
