Tg(Ttr-PROC*)#Bise
Transgene Detail
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| Symbol: |
Tg(Ttr-PROC*)#Bise |
| Name: |
transgene insertion, Berend Isermann |
| MGI ID: |
MGI:6755181 |
| Synonyms: |
APChigh |
| Transgene: |
Tg(Ttr-PROC*)#Bise Location: unknown
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| Alliance: |
Tg(Ttr-PROC*)#Bise page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Tg(Ttr-PROC*)#Bise expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
PROC (5624) |
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human cDNA with D167F and D172K codon changes (coordinates for mature peptide) |
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Mutation details: A cDNA for a mutagenized human protein C gene where D167F and D172K codon changes (D209F, D214K for pre-pro-peptide) were introduced, was placed in exon 2 in a 3 kb fragment containing the promoter and exons 1 and 2 of the liver-specific transthyretin gene. The mutations create a hyper-activatable form of the enzyme.
(J:130271)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:130271 Isermann B, et al., Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med. 2007 Nov;13(11):1349-58 |
| All: |
4 reference(s) |
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Analysis Tools
