Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Sh2b1tm3(cre)Lr
Name:	SH2B adaptor protein 1; targeted mutation 3, Liangyou Rui
MGI ID:	MGI:6754108
Synonyms:	Sh2b1-Cre
Gene:	Sh2b1  Location: Chr7:126066166-126074596 bp, - strand  Genetic Position: Chr7, 69.06 cM
Alliance:	Sh2b1tm3(cre)Lr page

Germline Transmission:	Earliest citation of germline transmission: J:289128
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase, Reporter) Mutation:    Insertion   Sh2b1tm3(cre)Lr expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Sh2b1 (MGI:1201407)   Mutation details: An IRES-EGFP-2A-Cre fragment was inserted at the Sh2b1 locus 3 to the STOP codon through ES cell homologous recombination. GFP levels in Sh2b1-Cre mice were below detection thresholds. (J:289128)

Activity:	Tissue activity of this recombinase allele
Driver:	Sh2b1 (mouse) Summary of all recombinase alleles driven by Sh2b1. Comparative matrix view of recombinase activities Alliance mouse Sh2b1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh2b1 Mutation:	48 strains or lines available

Original:	J:289128 Jiang L, et al., Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease. Nat Commun. 2020 Mar 23;11(1):1517
All:	1 reference(s)