Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Sox6tm2.1(cre/ERT2)Awar
Name:	SRY (sex determining region Y)-box 6; targeted mutation 2.1, Rajeshwar Awatramani
MGI ID:	MGI:6740239
Synonyms:	Sox6-CreERT2
Gene:	Sox6  Location: Chr7:115070107-115638031 bp, - strand  Genetic Position: Chr7, 61.29 cM
Alliance:	Sox6tm2.1(cre/ERT2)Awar page

Germline Transmission:	Earliest citation of germline transmission: J:290856
Parent Cell Line:	PRX-B6N (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Sox6tm2.1(cre/ERT2)Awar expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Sox6 (MGI:98368)   Mutation details: The FRT-STOP-Puro-FRT cassette was inserted into the intronic region between exons 2 and 3 and a NLS-Cre/ERT2-polyA was inserted into the Sox6 gene in-frame to the endogenous ATG. Flp-mediated recombination removed the STOP and selection cassette. (J:290856, J:321252)

Activity:	Tissue activity of this recombinase allele
Driver:	Sox6 (mouse) Summary of all recombinase alleles driven by Sox6. Alliance mouse Sox6 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox6 Mutation:	59 strains or lines available

Original:	J:290856 Poulin JF, et al., PRISM: A Progenitor-Restricted Intersectional Fate Mapping Approach Redefines Forebrain Lineages. Dev Cell. 2020 Jun 22;53(6):740-753.e3
All:	2 reference(s)