Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Grprem1(icre/ERT2)Ygs
Name:	gastrin releasing peptide receptor; endonuclease-mediated mutation 1, Yan-Gang Sun
MGI ID:	MGI:6740210
Synonyms:	GRPR-iCreERT2
Gene:	Grpr  Location: ChrX:162296900-162332673 bp, - strand  Genetic Position: ChrX, 75.63 cM
Alliance:	Grprem1(icre/ERT2)Ygs page

Strain of Origin:

C57BL/6

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Grprem1(icre/ERT2)Ygs expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Grpr (MGI:95836)   Mutation details: Using CRISPR/Cas9 technology, a cassette comprising of the 2A-linked optimized Cre recombinase fused with the ligand-binding domain of the estrogen receptor (2A-iCreERT2) was inserted in the Exon3 and 3UTR of Grpr gene. (J:244217)

Activity:	Tissue activity of this recombinase allele
Driver:	Grpr (mouse) Summary of all recombinase alleles driven by Grpr. Comparative matrix view of recombinase activities Alliance mouse Grpr gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grpr Mutation:	14 strains or lines available

Original:	J:244217 Mu D, et al., A central neural circuit for itch sensation. Science. 2017 Aug 18;357(6352):695-699
All:	4 reference(s)