About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:293793 Basta JM, et al., The core SWI/SNF catalytic subunit Brg1 regulates nephron progenitor cell proliferation and differentiation. Dev Biol. 2020 Aug 15;464(2):176-187
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6740180
Gene symbol: Lrp2
Gene name: low density lipoprotein receptor-related protein 2
Antibody: Anti-Lrp2/Megalin (ab76969)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5A Lrp1 Brg1flx/flx: embryonic day 16.5; Smarca4tm1.2Pcn/Smarca4tm1.2Pcn (more )
Note: Triple labeled: green - Megalin (Lrp2); red - cytokeratin; blue - DAPI.
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Present 5A Brg1flx/flx Megalin Formation of proximal tubules readily apparent.
Specimen 5A Lrp1 Six2Cre Brg1flx/flx: embryonic day 16.5; Smarca4tm1.2Pcn/Smarca4tm1.2Pcn, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: green - Megalin (Lrp2); red - cytokeratin; blue - DAPI.
Structure Level Pattern Image Note
TS24: cortical early distal tubule Weak 5A Six2Cre Brg1flx/flx Megalin Authors report 87% reduction in proximal tubules.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory