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Gene Expression Data
Assay Details
Assay
Reference: J:293793 Basta JM, et al., The core SWI/SNF catalytic subunit Brg1 regulates nephron progenitor cell proliferation and differentiation. Dev Biol. 2020 Aug 15;464(2):176-187
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6740180
Gene symbol: Lrp2
Gene name: low density lipoprotein receptor-related protein 2
Antibody: Anti-Lrp2/Megalin (ab76969)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5A Lrp1 Brg1flx/flx: embryonic day 16.5; Smarca4tm1.2Pcn/Smarca4tm1.2Pcn (more )
Note: Triple labeled: green - Megalin (Lrp2); red - cytokeratin; blue - DAPI.
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Present 5A Brg1flx/flx Megalin Formation of proximal tubules readily apparent.
Specimen 5A Lrp1 Six2Cre Brg1flx/flx: embryonic day 16.5; Smarca4tm1.2Pcn/Smarca4tm1.2Pcn, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: green - Megalin (Lrp2); red - cytokeratin; blue - DAPI.
Structure Level Pattern Image Note
TS24: cortical early distal tubule Weak 5A Six2Cre Brg1flx/flx Megalin Authors report 87% reduction in proximal tubules.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
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