Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Lrp4tm1.1(GFP/cre/ERT2)Gan
Name:	low density lipoprotein receptor-related protein 4; targeted mutation 1.1, Lin Gan
MGI ID:	MGI:6739898
Synonyms:	Lrp4-CreERT2
Gene:	Lrp4  Location: Chr2:91287856-91344124 bp, + strand  Genetic Position: Chr2, 50.63 cM
Alliance:	Lrp4tm1.1(GFP/cre/ERT2)Gan page

Germline Transmission:	Earliest citation of germline transmission: J:291055
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Lrp4tm1.1(GFP/cre/ERT2)Gan expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Lrp4 (MGI:2442252)   Mutation details: A targeting vector containing a 3' FRT flanked neo cassette and P2A-GFP-CreERT2 cassette was inserted to exon 38 of the Lrp4 gene via homologous recombination in C57BL/6J-derived embryonic stem cells. Heterozygous animals were crossed subsequently to FLP recombinase expressing mice to remove the FRT site flanked PGK-neo cassette. (J:291055)

Activity:	Tissue activity of this recombinase allele
Driver:	Lrp4 (mouse) Summary of all recombinase alleles driven by Lrp4. Comparative matrix view of recombinase activities Alliance mouse Lrp4 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp4 Mutation:	97 strains or lines available

Original:	J:291055 Zhang H, et al., A Role of Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4) in Astrocytic Abeta Clearance. J Neurosci. 2020 Jul 8;40(28):5347-5361
All:	2 reference(s)