Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Cpne7tm1.1(cre)Sleep
Name:	copine VII; targeted mutation 1.1, Yu Hayashi
MGI ID:	MGI:6739829
Synonyms:	Cpne7Cre, Cpne7-KO
Gene:	Cpne7  Location: Chr8:123844113-123861921 bp, + strand  Genetic Position: Chr8, 72.06 cM
Alliance:	Cpne7tm1.1(cre)Sleep page

Germline Transmission:	Earliest citation of germline transmission: J:291955
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout, Recombinase) Mutation:    Insertion   Cpne7tm1.1(cre)Sleep expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Cpne7 (MGI:2142747)   Mutation details: Via homologous recombination in ES cells, the targeting vector inserted a nuclear localization sequence(NLS)-Cre-FRT-PGK-gb2-neo-FRT cassette (Cre cassette) downstream of the Cpne7 promoter. The PGK-Neo cassette was removed by crossing mice with CAG-FLPe mice. The western blot of whole brain samples did not show the detectable level of Cpne7 protein in homozygous mice. It is a null allele. (J:291955)

Activity:	Tissue activity of this recombinase allele
Driver:	Cpne7 (mouse) Summary of all recombinase alleles driven by Cpne7. Comparative matrix view of recombinase activities Alliance mouse Cpne7 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cpne7 Mutation:	26 strains or lines available

Original:	J:291955 Liu CY, et al., Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice. Neurosci Res. 2020 Apr 11;
All:	1 reference(s)