Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Ncr1tm1(icre/ERT2)Tfen
Name:	natural cytotoxicity triggering receptor 1; targeted mutation 1, Todd A Fehniger
MGI ID:	MGI:6739825
Synonyms:	Ncr1-iCreERT2
Gene:	Ncr1  Location: Chr7:4340723-4348163 bp, + strand  Genetic Position: Chr7, 2.5 cM
Alliance:	Ncr1tm1(icre/ERT2)Tfen page

Germline Transmission:	Earliest citation of germline transmission: J:292090
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Ncr1tm1(icre/ERT2)Tfen expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ncr1 (MGI:1336212)   Mutation details: Via homologous recombination in ES cells, the targeting vector inserted tamoxifen-responsive iCreERT2 cassette into the Ncr1 locus linked to the C-terminal translation via a P2A ribosomal skip site. (J:292090)

Activity:	Tissue activity of this recombinase allele
Driver:	Ncr1 (mouse) Summary of all recombinase alleles driven by Ncr1. Alliance mouse Ncr1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncr1 Mutation:	39 strains or lines available

Original:	J:292090 Wagner JA, et al., Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity. Cell Rep. 2020 Jun 2;31(9):107720
All:	2 reference(s)