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Foxp2tm1.1(flpo)Tmj
Targeted Allele Detail
Summary
Symbol: Foxp2tm1.1(flpo)Tmj
Name: forkhead box P2; targeted mutation 1.1, Thomas M Jessell
MGI ID: MGI:6728072
Synonyms: FoxP2::Flpo
Gene: Foxp2  Location: Chr6:14901348-15441976 bp, + strand  Genetic Position: Chr6, 6.49 cM, cytoband A2
Alliance: Foxp2tm1.1(flpo)Tmj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:234419
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
 
Foxp2tm1.1(flpo)Tmj expression driven by 1 gene
 
Mutation detailsA codon-optimized version of FLP recombinase (Flpo) was inserted into the ATG in the 4th exon of the Fox2 genomic locus by ES cell recombination. The neomycin selectable cassette was removed by crossing with cre-deleter. This is a null allele as well as recombinase knock-in. (J:234419)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Foxp2 (mouse)
Summary of all recombinase alleles driven by Foxp2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxp2 Mutation:  52 strains or lines available
References
Original:  J:234419 Bikoff JB, et al., Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits. Cell. 2016 Mar 24;165(1):207-19
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory