Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Cdkn2atm2.1(cre/ERT2)Dvb
Name:	cyclin dependent kinase inhibitor 2A; targeted mutation 2.1, Dmitry V Bulavin
MGI ID:	MGI:6727120
Synonyms:	p16-CreERt2
Gene:	Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Alliance:	Cdkn2atm2.1(cre/ERT2)Dvb page

Germline Transmission:	Earliest citation of germline transmission: J:296551
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Cdkn2atm2.1(cre/ERT2)Dvb expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Cdkn2a (MGI:104738)   Mutation details: An F2A-Cre/ERT2-T2A-TK-E2A-tdTomato cassette was introduced at the end of the last exon of the Cdkn2a (p16Ink4) gene by homologous recombination in the ES cells. The Frt-loxed Neo cassette was removed by crossing with FLP deleter. (J:296551)

Activity:	Tissue activity of this recombinase allele
Driver:	Cdkn2a (mouse) Summary of all recombinase alleles driven by Cdkn2a. Comparative matrix view of recombinase activities Alliance mouse Cdkn2a gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:	62 strains or lines available

Original:	J:296551 Grosse L, et al., Defined p16(High) Senescent Cell Types Are Indispensable for Mouse Healthspan. Cell Metab. 2020 Jul 7;32(1):87-99.e6
All:	1 reference(s)