Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Runx1/Hspa1a-cre/ERT2)5-2Itoy
Name:	transgene insertion 5-2, Yoshiaki Ito
MGI ID:	MGI:6726405
Synonyms:	eR1-CreERT2(5-2)
Transgene:	Tg(Runx1/Hspa1a-cre/ERT2)5-2Itoy  Location: unknown
Alliance:	Tg(Runx1/Hspa1a-cre/ERT2)5-2Itoy page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Runx1/Hspa1a-cre/ERT2)5-2Itoy expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Runx1 (MGI:99852)   Mutation details: The transgenic construct contains mouse Runx1 enhancer element sequence (eR1) and the mouse Hspa1a (heat-shock protein 68) basal promoter sequence driving the expression of cre/ERT2. More than 10 founder lines were generated. The line TG(5-2) with higher copy number and TG(3-7) with lower copy number used for studies. Although the former had higher Cre recombinase activity than the latter, the results obtained using these lines were qualitatively indistinguishable. (J:299420)

Activity:	Tissue activity of this recombinase allele
Driver:	Runx1 (mouse) Summary of all recombinase alleles driven by Runx1. Comparative matrix view of recombinase activities Alliance mouse Runx1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:299420 Matsuo J, et al., Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice. Gastroenterology. 2017 Jan;152(1):218-231.e14
All:	3 reference(s)