Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Sox2tm1.1(cre/ERT2)Ykaw
Name:	SRY (sex determining region Y)-box 2; targeted mutation 1.1, Yoshiya Kawaguchi
MGI ID:	MGI:6724015
Synonyms:	Sox2CreERT2
Gene:	Sox2  Location: Chr3:34704554-34706610 bp, + strand  Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Alliance:	Sox2tm1.1(cre/ERT2)Ykaw page

Germline Transmission:	Earliest citation of germline transmission: J:301269
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Sox2tm1.1(cre/ERT2)Ykaw expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Sox2 (MGI:98364)   Mutation details: A CreERT2-pA-PGK-Bsd-pA replaced most of exon 1 after the first ATG of the Sox2 gene via homologous recombination in ES cells. Recombination removed the selection cassette. (J:301269)

Activity:	Tissue activity of this recombinase allele
Driver:	Sox2 (mouse) Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities Alliance mouse Sox2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox2 Mutation:	56 strains or lines available

Original:	J:301269 Sankoda N, et al., Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice. Nat Commun. 2021 Jan 25;12(1):560
All:	1 reference(s)