Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Cdh2em1(dre)Bzsh
Name:	cadherin 2; endonuclease-mediated mutation 1, Bin Zhou
MGI ID:	MGI:6720926
Synonyms:	N-cad-LSL-Dre
Gene:	Cdh2  Location: Chr18:16721934-16942303 bp, - strand  Genetic Position: Chr18, 10.1 cM
Alliance:	Cdh2em1(dre)Bzsh page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Conditional ready, Recombinase) Mutation:    Insertion   Cdh2em1(dre)Bzsh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Cdh2 (MGI:88355)   Mutation details: By genome editing using CRISPR-Cas9 technology, a cDNA containing loxp-stop-loxp-Dre-polyA (LSL-Dre) cassette was inserted into the translation start codon of the Cdh2 gene. To strengthen the stability of the transcripts, the woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) was also included following the Dre signal sequence. (J:297057)

Activity:	Tissue activity of this recombinase allele
Driver:	Cdh2 (mouse) Summary of all recombinase alleles driven by Cdh2. Alliance mouse Cdh2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdh2 Mutation:	50 strains or lines available

Original:	J:297057 Li Y, et al., Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. Dev Cell. 2020 Sep 14;54(5):593-607.e5
All:	1 reference(s)