Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Npvftm1.1(icre)Gand
Name:	neuropeptide VF precursor; targeted mutation 1.1, Greg M Anderson
MGI ID:	MGI:6720253
Synonyms:	RFRP-Cre
Gene:	Npvf  Location: Chr6:50627652-50631419 bp, - strand  Genetic Position: Chr6, 24.34 cM, cytoband B3
Alliance:	Npvftm1.1(icre)Gand page

Germline Transmission:	Earliest citation of germline transmission: J:300737
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Npvftm1.1(icre)Gand expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Npvf (MGI:1926488)   Mutation details: Using homologous recombination in mouse embryonic stem cells, an internal ribosomal entry sequence (IRES) linked to an improved cre recombinase gene and an FRT-flanked neomycin resistance gene was targeted into the 3' untranslated region immediately downstream of the termination codon within the Npvf gene. FLPe-deleter mice were crossed to remove the FRT-flanked neomycin selection cassette. (J:300737)

Activity:	Tissue activity of this recombinase allele
Driver:	Npvf (mouse) Summary of all recombinase alleles driven by Npvf. Comparative matrix view of recombinase activities Alliance mouse Npvf gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npvf Mutation:	5 strains or lines available

Original:	J:300737 Mamgain A, et al., RFamide-Related Peptide Neurons Modulate Reproductive Function and Stress Responses. J Neurosci. 2021 Jan 20;41(3):474-488
All:	1 reference(s)