Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm6(dre/PGR*)Dwi
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Douglas J Winton
MGI ID:	MGI:6719400
Synonyms:	RDrePr
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm6(dre/PGR*)Dwi page

Germline Transmission:	Earliest citation of germline transmission: J:301641
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    mifepristone Mutation:    Insertion   Gt(ROSA)26Sortm6(dre/PGR*)Dwi expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gt(ROSA)26Sor (MGI:104735)   Mutation details: A splice acceptor site was inserted immediately before the Dre and the mutated human progesterone receptor (PGR) consisting of the Ru486 responsive mutant hormone-binding domain hPR891 was fused to the N-terminus of Dre sequence followed by a bovine growth hormone (BGH) polyadenylation signal and PGK-Puro selection cassette. The targeting vector was inserted into a Gt(ROSA)26Sor site by homologous recombination in ES cells. (J:301641)

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Comparative matrix view of recombinase activities Alliance mouse Gt(ROSA)26Sor gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:301641 Thorsen AS, et al., Heterogeneity in clone dynamics within and adjacent to intestinal tumours identified by Dre-mediated lineage tracing. Dis Model Mech. 2020 Oct 22;:dmm046706
All:	1 reference(s)