Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gucy1b2tm4.1(cre)Mom
Name:	guanylate cyclase 1, soluble, beta 2; targeted mutation 4.1, Peter Mombaerts
MGI ID:	MGI:6719255
Synonyms:	Gucy1b2-IRES-nlsCre-IRES-taulacZ
Gene:	Gucy1b2  Location: Chr14:62630125-62693738 bp, - strand  Genetic Position: Chr14, 33.21 cM
Alliance:	Gucy1b2tm4.1(cre)Mom page

Germline Transmission:	Earliest citation of germline transmission: J:307157
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Recombinase, Reporter) Mutation:    Insertion   Gucy1b2tm4.1(cre)Mom expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gucy1b2 (MGI:2660873)   Mutation details: Sequence encoding an IRES followed by Cre recombinase with a nuclear localization signal followed by a second IRES and tau-lacZ followed by an FRT-flanked neomycin selection cassette was inserted immediately downstream of the stop codon, leaving the coding sequence intact with tri-cistronic expression resulting in the co-expression of nuclear-localized cre and the tau-lacZ reporter. Flp-mediated excision removed the neomycin selection cassette. (J:307157)

Activity:	Tissue activity of this recombinase allele
Driver:	Gucy1b2 (mouse) Summary of all recombinase alleles driven by Gucy1b2. Alliance mouse Gucy1b2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gucy1b2 Mutation:	33 strains or lines available

Original:	J:307157 Koike K, et al., Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide. Neuron. 2021 Jun;109:1-16
All:	1 reference(s)