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Gene Expression Data
Assay Details
Assay
Reference: J:75477 Takashima S, et al., Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3657-62
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6718829
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: MEC 13.3
Detection system: Secondary antibody coupled to alkaline phosphatase
Results
Specimen 3A: embryonic day 10.0; Nrp1tm1Hfu/Nrp1+, Nrp2tm1Mkl/Nrp2+ (more )
Structure Level Pattern Image Note
TS16: yolk sac blood vessel Present 3A Expression is in the endothelium in well organized blood vessels.
Specimen 3B: embryonic day 10.0; Nrp1tm1Hfu/Nrp1+, Nrp2tm1Mkl/Nrp2tm1Mkl (more )
Structure Level Pattern Image Note
TS16: yolk sac blood vessel Present 3B This mutant lacks large branching vessels and lacks a capillary network and has fused vessels and avascular regions.
Specimen 3C: embryonic day 10.0; Nrp1tm1Hfu/Nrp1tm1Hfu, Nrp2tm1Mkl/Nrp2+ (more )
Structure Level Pattern Image Note
TS16: yolk sac blood vessel Present 3C This mutant lacks large branching vessels and lacks a capillary network and has fused vessels and avascular regions.
Specimen 4A: embryonic day 10.0; Nrp1tm1Hfu/Nrp1+, Nrp2tm1Mkl/Nrp2+ (more )
Structure Level Pattern Image Note
TS16: blood vessel Present 4A Expression is in the endothelium in well organized blood vessels.
Specimen 4B: embryonic day 10.0; Nrp1tm1Hfu/Nrp1+, Nrp2tm1Mkl/Nrp2tm1Mkl (more )
Structure Level Pattern Image Note
TS16: blood vessel Present 4B This mutant has regions of avascularity and vessels were poorly formed and density was sparse with large avascular spaces between the blood vessels and some were thickened.
Specimen 4C: embryonic day 10.0; Nrp1tm1Hfu/Nrp1tm1Hfu, Nrp2tm1Mkl/Nrp2+ (more )
Structure Level Pattern Image Note
TS16: blood vessel Present 4C This mutant has regions of avascularity and vessels were poorly formed and density was sparse with large avascular spaces between the blood vessels and some were thickened.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/28/2026
MGI 6.24 		The Jackson Laboratory