Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Oprm1tm1.1(cre/ERT2)Dwata
Name:	opioid receptor, mu 1; targeted mutation 1.1, Dai Watanabe
MGI ID:	MGI:6718628
Synonyms:	MOR-CreER
Gene:	Oprm1  Location: Chr10:6708593-6988209 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Alliance:	Oprm1tm1.1(cre/ERT2)Dwata page

Germline Transmission:	Earliest citation of germline transmission: J:302775
Parent Cell Line:	EGR-101 (ES Cell)
Strain of Origin:	C57BL/6NSlc

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Oprm1tm1.1(cre/ERT2)Dwata expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Oprm1 (MGI:97441)   Mutation details: A bacterial artificial chromosome (BAC) containing the mouse Oprm1 gene (RP24-112H16) was modified so that the translational stop codon in exon 4 of the Oprm1 gene was replaced by a cassette comprising the T2A sequence, icre/ERT2 gene with stop codon and FRT-flanked neomycin-resistant gene (T2A-iCreERT2-FRT-Neo-FRT). The homologous recombination in the mouse ES cells generated a chimeric mouse which was crossed with CAG-FLPe mice to remove the FRT-flanked neomycin resistance cassette in the offspring. (J:302775)

Activity:	Tissue activity of this recombinase allele
Driver:	Oprm1 (mouse) Summary of all recombinase alleles driven by Oprm1. Comparative matrix view of recombinase activities Alliance mouse Oprm1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:	53 strains or lines available

Original:	J:302775 Okunomiya T, et al., Generation of a MOR-CreER knock-in mouse line to study cells and neural circuits involved in mu opioid receptor signaling. Genesis. 2020 Jan;58(1):e23341
All:	1 reference(s)