Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tbx1tm1.1(cre/ERT2)Zzhg
Name:	T-box 1; targeted mutation 1.1, Zhen Zhang
MGI ID:	MGI:6718614
Synonyms:	Tbx1E5C
Gene:	Tbx1  Location: Chr16:18399729-18409412 bp, - strand  Genetic Position: Chr16, Syntenic
Alliance:	Tbx1tm1.1(cre/ERT2)Zzhg page

Germline Transmission:	Earliest citation of germline transmission: J:303592
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tbx1tm1.1(cre/ERT2)Zzhg expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tbx1 (MGI:98493)   Mutation details: An IRES-CreERT2-polyA-SDA-Neo-SDA cassette was inserted into Xcm1 site within the exon 5, which encodes part of the T box domain resulting in a functionally null allele. The neo cassette was self-excised in the ES cells. (J:303592)

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx1 (mouse) Summary of all recombinase alleles driven by Tbx1. Comparative matrix view of recombinase activities Alliance mouse Tbx1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:	34 strains or lines available

Original:	J:303592 Wei L, et al., Pharyngeal epithelial deletion of Tbx1 causes caudal pharyngeal arch defect but not cardiac conotruncal anomaly. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1315-1322
All:	1 reference(s)